O-210. Desogestrel with s.c. testosterone pellets suppresses gonadotropins and spermatogenesis without affecting high density leukocyte concentration
نویسندگان
چکیده
منابع مشابه
Desogestrel plus testosterone effectively suppresses spermatogenesis but also causes modest weight gain and high-density lipoprotein suppression.
OBJECTIVE To test the hypothesis that oral desogestrel (DSG) plus testosterone would uniformly and rapidly suppress sperm concentrations in young men as effectively as levonorgestrel (LNG) plus testosterone and cause less high-density lipoprotein (HDL) suppression and weight gain. DESIGN Single-blind, randomized trial. SETTING VA Puget Sound and University of Washington, Seattle, Washington...
متن کاملSpermatogenesis without Gonadotropins: Maintenance Has a Lower Testosterone Threshold than Initiation1.
We showed previously that testosterone (T) alone could induce spermatogenesis and produce normally fertile spermatozoa in the absence of circulating gonadotropins. These studies used the hpg mouse, which is characterized by a congenital gonadotrophin deficiency due to a major deletion in the GnRH gene. Administering T by a subdermal implant of a SILASTIC brand tube impregnated with crystalline ...
متن کاملTestosterone, gonadotropins and androgen receptor during spermatogenesis of Biomphalaria alexandrina snails (Pulmonata: Basommatophora).
Endocrine regulation of reproductive processes of the snail Biomphalaria alexandrina is poorly recognized. Thus, the aims of the study were: (1) to acquire histological images of the ovotestis; (2) to determine the hemolymph concentrations of testosterone (T) and gonadotropic hormones (luteinizing hormone: LH and follicle stimulating hormone: FSH), (3) to demonstrate androgen receptor (AR) immu...
متن کاملInvestigation of hormonal male contraception in African men: suppression of spermatogenesis by oral desogestrel with depot testosterone.
BACKGROUND Suppression of spermatogenesis to azoospermia is required for effective hormonal male contraception, but the degree of suppression varies between ethnic groups. We here report the first study of hormonal suppression of spermatogenesis in two African centres using a regimen of oral progestogen with depot testosterone. METHODS A total of 31 healthy men (21 black) were recruited in Cape...
متن کاملO-28: High Maternal Hemoglobin Concentration and Preeclampsia
Background: High maternal hemoglobin concentration has been increasingly linked to poor pregnancy outcomes in recent years. This study was aimed to determine whether high maternal hemoglobin (Hb) in first trimester is associated with preeclampsia. Materials and Methods: In 2009 a retrospective study was conducted and demographic and obstetric records of 1513 low risk pregnant mother registered ...
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ژورنال
عنوان ژورنال: Human Reproduction
سال: 1997
ISSN: 1460-2350,0268-1161
DOI: 10.1093/humrep/12.suppl_2.104-a